Compensation Overview
Brisbane, CA, US: $252,640 - $306,137
Cambridge Crossing: $252,640 - $306,137
Princeton, NJ, US: $229,670 - $278,306
San Diego, CA, US: $252,640 - $306,137
Job Description
Brisk; Bristol Myers Squibb is seeking a strategic, scientifically grounded leader to serve as the Senior Director for Clinical Pharmacology & Pharmacometrics. This leader will partner deeply with Clinical Pharmacology, Pharmacometrics, Quantitative Pharmacology, and Translational Medicine stakeholders to deliver applications, modeling environments, workflow automation, and governed operational capabilities that support CPP work end-to-end—from quantitative preclinical-to-clinical bridging through clinical PK/PD, dose and regimen decisions, and submission‑support outputs.
This role supports the quantitative CPP layer across Research and Development, including pharmacometric workflows, clinical PK/PD systems, modeling platforms, reporting automation, regulatory evidence generation, and the governed operational capabilities required to run these workflows at scale.
Reporting to the Vice President of Research Business Insights & Technology, this leader will operate as part of a unified BI&T leadership team and act as a trusted partner to R&D leadership. The role carries accountability for the reliability, fit-for-purpose evolution, and long-term scaling of the CPP technology stack and workflow ecosystem, while working in a highly matrixed model with scientific leaders, data teams, lab‑platform teams, and regulatory-facing partners.
Mission & Impact
* Provide a scalable application and workflow backbone for CPP across preclinical-to-clinical translation, clinical PK/PD, dose selection, exposure-response, and model-informed development decisions.
* Improve the speed, quality, reproducibility, traceability, and inspection-readiness of pharmacometrics and clinical pharmacology workflows.
* Strengthen regulatory submissions through robust reporting, reusable quantitative evidence generation, and auditable outputs that support documents such as clinical pharmacology summaries and model‑based appendices.
* Enable governed automation of priority CPP workflows, including reporting, simulation, execution, review, and knowledge reuse.
* Create a durable technology foundation for end-to-end CPP that can scale with pipeline demand and integrate cleanly across the broader R&D ecosystem.
Key Responsibilities
* Serve as the single BI&T point of accountability for CPP technology, applications, workflows, and support services end-to-end.
* Partner across R&D to integrate CPP workflows with scientific, data, and operational capabilities required for model-informed drug development.
* Own clinical pharmacology and pharmacometrics applications, modeling environments, reporting workflows, and operational support for core CPP use cases.
* Ensure operational excellence, reliability, governance, and continuous improvement across modeling environments, clinical PK/PD systems, reporting workflows, and submission‑support applications.
* Lead automation of priority CPP workflows, including model execution, reporting, simulation, traceability, review, and evidence reuse.
* Support quantitative regulatory deliverables through fit-for-purpose tooling, reproducible workflows, and inspection-ready practices.
* Partner with Unified Lab & Experimental Platforms, Target & Disease Biology, and In‑Vivo & Non-Clinical Pharmacology where translational science, lab systems, diagnostics, biomarker workflows, or bioanalytical capabilities intersect with CPP needs.
* Partner with the R&D Data organization on underlying data-product strategy, integration, and fit-for-purpose data access.
* Lead and grow a team of scientific technologists, product leaders, and specialized engineers aligned to this domain.
Qualifications
* Ph.D. in Pharmacometrics, Clinical Pharmacology, Pharmaceutical Sciences, Biostatistics, or related quantitative field.
* 12+ years in pharmaceutical R&D with deep clinical pharmacology, pharmacometrics, and model-informed drug development experience.
* Proven experience implementing or leading CPP applications, PBPK and QSP environments, clinical PK/PD systems, or quantitative workflow automation.
* Demonstrated experience supporting regulatory submissions, quantitative reporting, and governed workflows in development-facing settings.
* Experience applying AI/ML or advanced automation to quantitative modeling, reporting, or regulated scientific workflows is preferred.
* Director or Senior Director‑level leadership experience; experience building and scaling a specialized scientific technology team is a strong differentiator.
Critical Capabilities
* Scientific depth in Clinical Pharmacology and Pharmacometrics—deep credibility with quantitative scientists and domain leaders across CPP.
* Strategic partnership—translates scientific and development needs into practical, integrated technology and workflow solutions.
* Operational leadership—builds reliable, scalable, inspection-ready environments and support models for critical quantitative workflows.
* Regulatory translation capability—understands how quantitative evidence is prepared, reported, reviewed, and used in regulatory settings.
Leadership & Change Attributes
* Strong partnership with senior scientific, clinical, and regulatory leaders.
* Comfort operating with regulatory and global development stakeholders.
* Ability to recruit, develop, and retain highly specialized quantitative talent in a competitive market.
* Experience navigating matrixed organizations and building credibility quickly.
* Commitment to building a collaborative, high-performing culture in a growing team.
What Differentiates Top Candidates
* Experience as a clinical pharmacology or pharmacometrics technology leader inside a top-tier pharmaceutical R&D organization.
* Track record of applications, workflows, or platforms that improved dose selection, quantitative decision-making, or regulatory execution in development-facing settings.
* Experience deploying workflow automation, AI-enabled capabilities, or advanced analytics in support of end-to-end CPP modeling, reporting, and decision-support operations.
* Demonstrated success building a specialized function from foundational capability to scaled organizational value while operating through strong matrix partnerships.
Why This Role Matters Now
Bristol Myers Squibb is at a pivotal moment, reimagining how technology, data, and AI enable scientific decision-making across R&D. Clinical pharmacology and pharmacometrics sit at the center of that shift, shaping how teams translate preclinical insights, make dose and regimen decisions, generate regulatory evidence, and advance programs with greater speed and rigor. This role is central to building the next generation of CPP capabilities, ensuring that scientists have the tools, automation, and integrated workflows needed to improve quality, reuse, and accountability across the pipeline.
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