As the Medicinal Chemist, you will be responsible for the design, synthesis, and optimisation of peptide-based ligands for targeted radiopharmaceutical development. You will work closely with radiochemistry, CMC, and preclinical teams and contribute to the discovery and development of new drug candidates with therapeutic potential.
Who will you be working with?
Our client is a clinical-stage radiopharmaceutical company developing treatments to significantly improve survival and quality of life for patients with cancer. As they continue to make advancements in their product development and clinical phases, there are multiple opportunities available to join this high-performing manufacturing team.
What are the benefits?
* Opportunity to launch your career with a team that will nurture growth.
* Competitive salary package + relocation support (if required).
* Join a team of experts.
* Culture of teamwork towards common goals.
What will you be doing?
* Design and synthesise peptide-based ligands for the company's development pipeline.
* Purify and characterise peptides using HPLC, LC-MS, NMR, and other analytical techniques.
* Support hit-to-lead and lead optimisation efforts with high-throughput synthesis and screening approaches.
* Conduct structure–activity relationship (SAR) studies to optimise binding affinity, selectivity, and pharmacokinetic properties.
* Collaborate with radiochemistry teams to ensure compatibility of peptide scaffolds with chelation and radiolabelling strategies.
* Document and present experimental results to specialised and multidisciplinary project teams.
* Maintain accurate laboratory records and contribute to documentation and other functions essential to keep the lab running smoothly.
What do you need?
* PhD in Medicinal Chemistry, Organic Chemistry, Peptide Chemistry, or related discipline (or MSc with extensive experience).
* Substantial experience in synthetic organic chemistry, with skills in SPPS and cyclic peptides.
* Familiarity with bioactive peptide design, non-natural amino acids, cyclisation strategies, and linker technologies.
* Experience with analytical characterisation methods including LC-MS, HPLC, and NMR.
* Excellent problem-solving skills and a collaborative mindset.
And at least two of the following:
* Experience with molecular modelling, or ligand-protein docking.
* Experience with biophysical characterisation techniques, such as binding assays using BLI, SPR, ELISA, or other fluorescence/plate-based techniques.
* Skills in PK characterisation, including but not limited to serum/plasma stability assays.
* Open to working with radioactivity and obtaining a radiation use license.
Note that this role involves working with radiation products in a safety-controlled and regulated environment, so you must be comfortable working in this environment and maintaining a Queensland Radiation Use Licence (provided by the company).
Please contact Christelle at ccapini@fuserecruitment.com or apply now.
At Fuse, we specialise in recruitment for the scientific and manufacturing industry, and actively source a variety of roles for a broad range of organisations. If you are looking for a new opportunity, we'd love to hear from you
If you know someone looking for a job, refer them to us and we'll give you $500* if we find them a new role
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